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15-Aug-2015 00:00

Where results were clear, 3 out of 185 exome sites (1.6%), 5 out of 281 low-coverage sites (1.8%) and 72 out of 3,415 large deletions (2.1%) could not be validated (Supplementary Information and Supplementary Tables 4–9). R.-F.; DP2OD6514 and BAA-NIAID-DAIT-NIHAI2009061 to P. million bi-allelic indels and 14,000 large deletions (Table 1). Several technologies were used to validate a frequency-matched set of sites to assess and control the false discovery rate (FDR) for all variant types.

Characterizing such variants, for both point mutations and structural changes, across a range of populations is thus likely to identify many variants of functional importance and is crucial for interpreting individual genome sequences, to help separate shared variants from those private to families, for example. H.; HHSN268201100040C to the Coriell Institute for Medical Research; a Sandler Foundation award and an American Asthma Foundation award to E. B.; an IBM Open Collaborative Research Program award to Y. We now report on the genomes of 1,092 individuals sampled from 14 populations drawn from Europe, East Asia, sub-Saharan Africa and the Americas (Supplementary Figs 1 and 2), analysed through a combination of low-coverage (2–6×) whole-genome sequence data, targeted deep (50–100×) exome sequence data and dense SNP genotype data (Table 1 and Supplementary Tables 1–3). By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Y.; and a Mary Beryl Patch Turnbull Scholar Program award to K. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing.

We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. Do.; a Howard Hughes Medical Institute International Fellowship award to P. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations.



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