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On the evolution of the show, Chuck Lorre said, "We did the 'Big Bang Pilot' about two and a half years ago, and it sucked...The Big Bang Theory (often shortened to Big Bang Theory, and abbreviated to TBBT or BBT) is an American television sitcom created by Chuck Lorre and Bill Prady, both of whom serve as executive producers on the series, along with Steven Molaro. The geekiness and intellect of the four guys are contrasted for comic effect with Penny's social skills and common sense. The show is primarily centered on five characters living in Pasadena, California: Leonard Hofstadter and Sheldon Cooper, both physicists at Caltech, who share an apartment; Penny, a waitress and aspiring actress who later becomes a pharmaceutical representative and who lives across the hall; and Leonard and Sheldon's similarly geeky and socially awkward friends and co-workers, aerospace engineer Howard Wolowitz and astrophysicist Raj Koothrappali.Over time, supporting characters have been promoted to starring roles: Bernadette Rostenkowski, Howard's girlfriend (later his wife), a microbiologist and former part-time waitress alongside Penny; neuroscientist Amy Farrah Fowler, who joins the group after being matched to Sheldon on a dating website (and later becomes Sheldon's girlfriend); Stuart Bloom, the cash-strapped owner of the comic book store the characters often visit; Leslie Winkle, a physicist who dated Leonard and Howard; and Emily Sweeney, a dermatologist who dated Raj and had a fascination with the macabre.The structure of the original, unaired pilot, developed for the 2006–07 television season, was substantially different from the series' current form.and Iris Bahr as Gilda, a scientist colleague and friend of the male characters.Sheldon and Leonard meet Katie after she breaks up with a boyfriend and they invite her to share their apartment; Gilda is threatened by Katie's presence.
Test audiences reacted negatively to Katie, but they liked Sheldon and Leonard.
The original pilot used Thomas Dolby's hit "She Blinded Me with Science" as the theme song.