His uncles were director Subodh Mukherjee, Ashok Kumar, Anoop Kumar and Kishore Kumar. Most of his movies had hit music (Ek Musafir Ek Haseena, Aao Pyar Karen, Shagird, Phir Wohi Dil Laya Hoon, Ek Baar Muskura Do, Door Ki Aawaz, Jee Chahta Hai, Humsaya, etc.) By the late 1960s acting roles began drying up, so he began directing and producing.
He produced and directed Humsaya although neither that film nor his subsequent films as producer or director did well.
After this initial success in her career, Mukerji's films fared poorly at the box office for the next three years.
Jai Om Yadav Mukherjee was the son of Sashadhar Mukherjee and Sati Devi. His wife's name is Neelam and they had two sons Monjoy (also known as Toy), Sujoy (also known as Boy) and a daughter Simran. After Love in Simla, he paired with Asha Parekh for several hits like Phir Wohi Dil Laya Hoon, Love in Tokyo and Ziddi.
His father was a successful producer and a co-founder of Filmalaya Studios. Joy debuted opposite Sadhana in the film Love in Simla (1960) directed by R. Some of his films like Door Ki Aawaz, Aao Pyar Karen and Shagird (opposite Saira Bano), Ek Musafir Ek Haseena with Sadhna, 'Ishaara' with Vyjayantimala and 'Jee Chahta Hai' with Rajashree were superhit movies.